ESSENTIAL OXYGEN TRANSPORT & DELIVERY 101
Aerobic glycolysis occurs within the mitochondria.
Here, high amounts of 38 ATP are generated in exchange for 8 electrons occurring within a process called aerobic glycolysis – requiring oxygen to work.
In contrast, when there are limitations of available oxygen supply – the body can still produce limited 2 ATP via a process called Anaerobic metabolism.
This occurs when oxygen transport and tissue oxygenation are compromised. This can be a result of hypoxemia, anemia, inadequate systemic blood flow, or a combination of these factors. Anaerobic metabolism leads to a rise in lactate levels, which therefore can be a marker of low cardiac output.
O2 is coupled with two
electron carrier coenzymes NAD & FAD and are used to transport electrons from the Krebs cycle to the respiratory chain.
The Krebs cycle is the second of three stages of cellular respiration, in which glucose, fatty acids and certain amino acids, the so-called fuel molecules, are oxidized.
Due to the many functions of the citric acid cycle is also considered to be the “central hub of metabolism”.
This is because, as most of the absorbed nutrients, the fuel molecules are oxidised ultimately within the Krebs Cycke and its intermediates are used for various biosynthetic pathways.
- NAD+ papers